2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-140542
    N-Benzyl-N-bis(PEG3-acid) 2093154-03-9
    N-Benzyl-N-bis(PEG3-acid) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    N-Benzyl-N-bis(PEG3-acid)
  • HY-141262
    Methyltetrazine-PEG24-amine 2353410-18-9
    Methyltetrazine-PEG24-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Methyltetrazine-PEG24-amine
  • HY-140268
    DBCO-PEG8-acid 2765066-35-9
    DBCO-PEG8-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-PEG8-acid is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-PEG8-acid
  • HY-133069
    Tos-PEG2-C2-Boc 850090-13-0
    Tos-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Tos-PEG2-C2-Boc
  • HY-140840
    Boc-NH-PEG9-azide 2112731-50-5
    Boc-NH-PEG9-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Boc-NH-PEG9-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Boc-NH-PEG9-azide
  • HY-W143484
    Fmoc-PEG3-alcohol 560088-66-6
    Fmoc-PEG3-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-PEG3-alcohol
  • HY-134733
    N-Ethyl-N-methylpropionamide-PEG1-Br 1695856-63-3
    N-Ethyl-N-methylpropionamide-PEG1-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    N-Ethyl-N-methylpropionamide-PEG1-Br
  • HY-117028
    Tos-PEG7-OH 1028089-05-5
    Tos-PEG7-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Tos-PEG7-OH
  • HY-140370
    Tos-PEG9-Tos 109635-64-5
    Tos-PEG9-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Tos-PEG9-Tos
  • HY-133460
    Tetrazine-Ph-NHCO-PEG3-alcohol
    Tetrazine-Ph-NHCO-PEG3-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Tetrazine-Ph-NHCO-PEG3-alcohol is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
    Tetrazine-Ph-NHCO-PEG3-alcohol
  • HY-140583
    N-Desthiobiotin-N-bis(PEG4-NHS ester) 2353409-61-5
    N-Desthiobiotin-N-bis(PEG4-NHS ester) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    N-Desthiobiotin-N-bis(PEG4-NHS ester)
  • HY-138450
    Br-PEG4-methyl acetate
    Br-PEG4-methyl acetate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Br-PEG4-methyl acetate
  • HY-140849
    Azido-PEG3-Ala-Boc 2054345-68-3
    Azido-PEG3-Ala-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG3-Ala-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG3-Ala-Boc
  • HY-141308
    m-PEG5-phosphonic acid 1807512-39-5
    m-PEG5-phosphonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG5-phosphonic acid
  • HY-140667
    Azide-PEG-azide (MW 20000)
    Azide-PEG-azide (MW 20000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azide-PEG-azide (MW 20000) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azide-PEG-azide (MW 20000)
  • HY-133320
    N3-PEG16-Hydrazide
    N3-PEG16-Hydrazide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N3-PEG16-Hydrazide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N3-PEG16-Hydrazide
  • HY-141052
    N-methyl-N'-methyl-O-(m-PEG4)-O'-(propargyl-PEG4)-Cy5 2107273-50-5
    N-methyl-N'-methyl-O-(m-PEG4)-O'-(propargyl-PEG4)-Cy5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-methyl-N'-methyl-O-(m-PEG4)-O'-(propargyl-PEG4)-Cy5 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    N-methyl-N'-methyl-O-(m-PEG4)-O'-(propargyl-PEG4)-Cy5
  • HY-132092
    Methyl-PEG3-Ald 141981-62-6
    Methyl-PEG3-Ald is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Methyl-PEG3-Ald
  • HY-126917
    THP-PEG5-OH 146395-14-4
    THP-PEG5-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    THP-PEG5-OH
  • HY-130416
    Mal-PEG2-PFP ester 1807512-47-5
    Mal-PEG2-PFP ester is a Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs.
    Mal-PEG2-PFP ester
PROTAC Linkers Isoform Comparison

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